Source:http://www.reactome.org/biopax/48887BiochemicalReaction1774
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Authored: Rothfels, K, 2011-08-15,
Reviewed: Gotoh, N, 2011-08-26,
Tyrosine phosphorylated FRS2 recruits GRB2:SOS1 complex by means of the SH3 domain of GRB2, leading to RAS-MAP kinase activation. The FRS2:GRB2-mediated pathway plays a minor role in the activation of RAS-MAP kinase pathway compared to that mediated by FRS2:SHP2.
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http://identifiers.org/pubmed/11353842,
http://identifiers.org/pubmed/11447289,
http://identifiers.org/pubmed/7559490,
http://identifiers.org/pubmed/8780727,
http://identifiers.org/pubmed/9182757,
urn:biopax:UnificationXref:REACTOME DATABASE ID_1268255,
urn:biopax:UnificationXref:REACTOME_REACT_111204_1
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GRB2:SOS1 binds to p-FRS2:activated FGFR
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