Source:http://www.reactome.org/biopax/48887BiochemicalReaction1773
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Authored: de Bono, B, 2007-01-10 10:27:18,
Edited: Jupe, S, 2010-02-03,
Reviewed: Gotoh, N, 2011-08-26,
Reviewed: Mohammadi, M, 2007-02-06 21:44:35,
Tyrosine phosphorylation of SHP2 by FGFR kinase is required for activation of the phosphatase activity of SHP2 and for downstream signaling. Tyrosine phosphorylated SHP2 plays a major role in the activation of RAS-MAP kinase pathway, although the precise role is not yet clear.
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SHP2 is phosphorylated by activated FGFR
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2.7.10
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