Source:http://www.reactome.org/biopax/48887BiochemicalReaction1768
| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
Authored: Rothfels, K, 2011-08-15,
FRS2alpha is broadly expressed in adult and fetal tissues. Membrane-bound FRS2alpha interacts with FGFR as a first step in the phosphorylation of this docking protein. The juxtamembrane binding site for FRS2alpha does not contain tyrosine, so binding may be independent of receptor activation and/or constitutive. Activation of the FGFR receptor is required for FRS2alpha phosphorylation and subsequent recruitment of downstream effectors.,
Reviewed: Gotoh, N, 2011-08-26
|
| biopax3:xref | |
| biopax3:dataSource | |
| biopax3:displayName |
Activated FGFR binds FRS2alpha
|
| biopax3:left | |
| biopax3:right |