Source:http://www.reactome.org/biopax/48887BiochemicalReaction1763
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Authored: de Bono, B, 2007-01-10 10:27:18,
Edited: de Bono, B, D'Eustachio, P, 2007-02-10 20:21:22,
Reviewed: Mohammadi, M, 2007-02-06 21:44:35,
The intrinsic protein tyrosine kinase activity of activated FGF receptor 4 catalyzes multiple phosphorylation events, creating a number of binding sites for membrane bound docking proteins to gather intracellular signaling mediators. Based on sequence alignment, FGFR4 contains 5 of the 8 cytoplasmic tyrosine residues identified in FGFR1.
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Autocatalytic phosphorylation of FGFR4
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2.7.10
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