Source:http://www.reactome.org/biopax/48887BiochemicalReaction1748
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| biopax3:comment |
Acyl ghrelin and C-ghrelin are secreted from secretory granules into the bloodstream. Five forms of acyl ghrelin have been detected: octanoyl ghrelin-28, decanoyl ghrelin-28, octanoyl ghrelin-27, decanoyl ghrelin-27, and decenoyl ghrelin-28. Unacylated ghrelin (des-acyl ghrelin) occurs at higher levels than acyl ghrelin however its function and mechanism of generation are controversial. The function, if any, of C-ghrelin is also unknown.<br>Secretion of ghrelin is stimulated by insulin-like growth factor-1 and muscarinic agonists; Secretion is inhibited by insulin, somatotropin, leptin, glucose, glucagon, and fatty acids. Carbohydrates have more inhibitory effect than fat does. The mechanisms by which the regulation is effected are unknown.,
Authored: May, B, 2009-06-10,
Edited: May, B, 2009-06-10,
Reviewed: Zhang, Weizhen, 2009-08-29
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| biopax3:xref |
http://identifiers.org/pubmed/11089560,
http://identifiers.org/pubmed/11600536,
http://identifiers.org/pubmed/11756331,
http://identifiers.org/pubmed/12354137,
http://identifiers.org/pubmed/12553549,
http://identifiers.org/pubmed/14599721,
http://identifiers.org/pubmed/15126574,
http://identifiers.org/pubmed/17595255,
http://identifiers.org/pubmed/18396350,
http://identifiers.org/pubmed/19280057,
urn:biopax:UnificationXref:REACTOME DATABASE ID_422048,
urn:biopax:UnificationXref:REACTOME_REACT_19136_2
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| biopax3:dataSource | |
| biopax3:displayName |
Secretion of Acyl Ghrelin and C-Ghrelin
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