Source:http://www.reactome.org/biopax/48887BiochemicalReaction1746
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Authored: May, B, 2009-06-10,
Edited: May, B, 2009-06-10,
Proghrelin is decanoylated by ghrelin O-acyltransferase (GOAT/MBOAT4), an enzyme present in the endoplasmic reticulum membrane which both transports the decanoic acid substrate and condenses it on the hydroxyl group of serine-3 of the mature protein. The most common acylated form of ghrelin is octanoyl ghrelin but decanoyl ghrelin is also detected in plasma. GOAT is able to use substrates up to tetradecanoic acid. Ghrelin is the only protein known to undergo such a modification.,
Reviewed: Zhang, Weizhen, 2009-08-29
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http://identifiers.org/pubmed/12414809,
http://identifiers.org/pubmed/18396350,
http://identifiers.org/pubmed/18443287,
http://identifiers.org/pubmed/19280057,
http://identifiers.org/pubmed/19628676,
urn:biopax:UnificationXref:REACTOME DATABASE ID_422017,
urn:biopax:UnificationXref:REACTOME_REACT_19329_2
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Decanoylation of Proghrelin by Ghrelin O-acyltransferase
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