Source:http://www.reactome.org/biopax/48887BiochemicalReaction1732
| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
Edited: May, B, Gopinathrao, G, 2008-11-19 20:02:07,
IGFBP 5 binds IGF I or IGF II via the conserved N terminus and C terminus of IGFBP 5. IGFBP 5 also binds ALS via the central portion of IGFBP 5. About 55% of IGF:IGFBP 5 complexes contain ALS. IGFBP 5 is enriched in bone matrix and acts to stimulate IGF function. IGFBP 5 is cleaved by Pregnancy associated Plasma Protein A2 (PAPP A2), ADAM 9, complement C1s from smooth muscle, and thrombin. Only the cleavage site for PAPP A2 is known. About 55% of IGF:IGFBP 5 complexes contain ALS; 45% contain only IGF and IGFBP 5.,
Reviewed: D'Eustachio, P, Matthews, L, Gillespie, ME, 2008-12-02 16:25:31
|
| biopax3:xref |
http://identifiers.org/pubmed/10614670,
http://identifiers.org/pubmed/10810289,
http://identifiers.org/pubmed/11316783,
http://identifiers.org/pubmed/11788658,
http://identifiers.org/pubmed/12379487,
http://identifiers.org/pubmed/12466191,
http://identifiers.org/pubmed/15126567,
http://identifiers.org/pubmed/17047378,
http://identifiers.org/pubmed/7519608,
http://identifiers.org/pubmed/7683646,
http://identifiers.org/pubmed/7689487,
http://identifiers.org/pubmed/8781553,
http://identifiers.org/pubmed/9497324,
http://identifiers.org/pubmed/9786878,
urn:biopax:UnificationXref:REACTOME DATABASE ID_381545,
urn:biopax:UnificationXref:REACTOME_REACT_15355_2
|
| biopax3:dataSource | |
| biopax3:displayName |
Formation of the IGF:IGFBP-5:ALS Complex
|
| biopax3:left | |
| biopax3:right |