Source:http://www.reactome.org/biopax/48887BiochemicalReaction1723
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Authored: May, B, 2009-06-03,
Edited: May, B, 2009-06-03,
Phosphorylated IRE1-alpha homodimers with bound ADP have endoribonuclease activity in their C-terminal (cytosolic) regions. The IRE1-alpha homodimers cleave an internal 26 nucleotide segment out of the Xbp-1 mRNA. In yeast the resulting RNAs are ligated by a tRNA ligase but the corresponding human ligase has not been identified. The cleavage and ligation leads to a frameshift in the Xbp-1 mRNA which results in a longer ORF that encodes Xbp-1 (S), the active form of the Xbp-1 transcription factor,
Reviewed: D'Eustachio, P, Matthews, L, Gillespie, ME, 2008-12-02 16:25:31,
Reviewed: Urano, F, 2010-04-30
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Cleavage of Xbp1 mRNA by IRE1alpha and Splicing of Cleaved Xbp1 mRNA
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