Source:http://www.reactome.org/biopax/48887BiochemicalReaction1721
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Authored: May, B, 2009-06-02 00:51:49,
Dimerization of the N-terminal luminal regions of IRE1-alpha brings the cytosolic C-terminal regions in proximity. The C-terminal region possesses kinase activity and the homodimer trans-autophosphorylates. From homology with Saccharomyces IRE1-alpha the phosphorylation of human IRE1-alpha is believed to be at Ser724.,
Edited: May, B, 2009-06-02 00:51:49,
Reviewed: D'Eustachio, P, Matthews, L, Gillespie, ME, 2008-12-02 16:25:31,
Reviewed: Urano, F, 2010-04-30
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Autophosphorylation of IRE1 dimer
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2.7.11
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