Source:http://www.reactome.org/biopax/48887BiochemicalReaction1719
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Authored: May, B, 2009-06-02 00:51:49,
Edited: May, B, 2009-06-02 00:51:49,
IRE1-alpha is a single-pass transmembrane protein with a luminal N-terminus and a cytoplasmic C-terminus. IRE1-alpha is maintained in an inactive state in the Endoplasmic Reticulum (ER) membrane by interaction between the luminal domain of IRE1-alpha and the ATPase domain of BiP within the ER. <br>BiP is a general chaperone that also binds unfolded proteins within the ER. Thus BiP dissociates from IRE1-alpha when chaperone activity is overwhelmed by unfolded proteins in the ER.,
Reviewed: D'Eustachio, P, Matthews, L, Gillespie, ME, 2008-12-02 16:25:31,
Reviewed: Urano, F, 2010-04-30
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Dissociation of IRE1:BiP heterodimer
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