Linked Life Data

48887BiochemicalReaction1677

Source:http://www.reactome.org/biopax/48887BiochemicalReaction1677

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Authored: Orlic-Milacic, M, 2011-11-04, Edited: D'Eustachio, P, 2011-11-07, Edited: Matthews, L, 2011-11-07, Edited: Wu, G, 2011-11-07, Reviewed: Greulich, H, 2011-11-15, Reviewed: Savas, S, 2011-11-15, The kinase activity of PI3K mediates the phosphorylation of PIP2 to form PIP3. It is assumed that EGFR cancer mutants induce PI3K/AKT signaling in a manner similar to wild-type EGFR. Phosphorylation of AKT on serine residue S473, and therby activation of PI3K/AKT signaling cascade, has been directly demonstrated in cells expressing the following EGFR cancer mutants: EGFR L858R mutant (Sordella et al. 2004, Paez et al. 2004, Greulich et al. 2005, Shimamura et al. 2005); EGFR G719S mutant (Greulich et al. 2005); EGFR E746_A750del mutant (Sordella et al. 2004, Shimamura et al. 2005); EGFR L747_P753insS mutant (Sordella et al. 2004); EGFR L747_A750delinsP mutant (Greulich et al. 2005); EGFR L861Q mutant (Lee et al. 2006); EGFR D770_N771insNPG mutant (Greulich et al. 2005, Xu et al. 2007); EGFR D770_N771insNPH mutant (Xu et al. 2007); EGFR V738_K739insKIPVAI mutant (Xu et al. 2007); EGFR M766_A767insASV mutant (Xu et al. 2007); EGFR E746_A750del;T790M double mutant (Shimamura et al. 2005).
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Conversion of PIP2 to PIP3 by PI3K bound to phosphorylated EGFR mutants
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2.7.1.153
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