Source:http://www.reactome.org/biopax/48887BiochemicalReaction1642
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Authored: Castagnoli, L, 2006-10-10 13:09:34,
Edited: Orlic-Milacic, Marija, 2011-08-25,
Phosphorylation at tyrosine Y1045 of EGFR creates a major docking site for E3 ubiquitin-protein ligase, CBL (Casitas B-lineage lymphoma proto- oncogene) and is required to sort the EGFR to lysosomes for degradation. The E3 ligase CBL plays a crucial role in these events as it dually participates in early events of internalization via a CIN85-endophilin dependent mechanism and endocytic sorting by mediating multiple monoubiquitylation of the receptor.,
Reviewed: Heldin, CH, 2008-02-12 09:44:02
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Binding of CBL to EGFR
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