Source:http://www.reactome.org/biopax/48887BiochemicalReaction1634
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Authored: Castagnoli, L, 2006-10-10 13:09:34,
Edited: Orlic-Milacic, Marija, 2011-08-25,
Reviewed: Heldin, CH, 2008-02-12 09:44:02,
The pleckstrin homology (PH) domain of GAB1 binds to PIP3 and can target GAB1 to the plasma membrane in response to EGF stimulation. This mechanism provides a positive feedback loop with respect to PI3K activation, to enhance EGFR signalling.
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Gab1 binds phosphatidylinositol-3,4,5-trisphosphate
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