Source:http://www.reactome.org/biopax/48887BiochemicalReaction1616
| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
Authored: Nasi, S, Annibali, D, 2006-10-10 09:07:07,
Once AKT is localized at the plasma membrane, it is phosphorylated at two critical residues for its full activation. These residues are a threonine (T308 in AKT1) in the activation loop within the catalytic domain, and a serine (S473 in AKT1), in a hydrophobic motif (HM) within the carboxy terminal, non catalytic region. PDK1 is the activation loop kinase; this kinase can also directly phosphorylate p70S6K. As detailed in the following events, the HM kinase, previously termed PDK2, has been identified as the mammalian TOR (Target Of Rapamycin; Sarbassov et al., 2005) but several other kinases are also able to phosphorylate AKT at S473.,
Reviewed: Greene, LA, 2007-11-08 15:39:37
|
| biopax3:xref | |
| biopax3:dataSource | |
| biopax3:displayName |
PDK1 phosphorylates AKT at T308
|
| biopax3:eCNumber |
2.7.11
|
| biopax3:left | |
| biopax3:right |