Source:http://www.reactome.org/biopax/48887BiochemicalReaction1610
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Authored: Castagnoli, L, 2006-10-10 13:09:34,
Edited: Orlic-Milacic, Marija, 2011-08-25,
Reviewed: Heldin, CH, 2008-02-12 09:44:02,
SOS1 is the guanine nucleotide exchange factor (GEF) for RAS. SOS1 activates RAS nucleotide exchange from the inactive form (bound to GDP) to an active form (bound to GTP).
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SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1)
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