Source:http://www.reactome.org/biopax/48887BiochemicalReaction1606
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Authored: Castagnoli, L, 2006-10-10 13:09:34,
Edited: Orlic-Milacic, Marija, 2011-08-25,
Reviewed: Heldin, CH, 2008-02-12 09:44:02,
The guanine nucleotide exchange factor SOS1 interacts with EGFR through the adaptor protein, GRB2. Upon formation of this complex, SOS activates RAS by promoting GDP release and GTP binding.
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SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1)
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