Source:http://www.reactome.org/biopax/48887BiochemicalReaction1605
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Authored: Castagnoli, L, 2006-10-10 13:09:34,
Cytoplasmic target proteins containing the SH2 domain can bind to activated EGFR. One such protein, growth factor receptor-bound protein 2 (GRB2), can bind activated EGFR with its SH2 domain whilst in complex with SOS through its SH3 domain. GRB2 can bind at either Y1068 and/or Y1086 tyrosine autophosphorylation sites on the receptor.,
Edited: Orlic-Milacic, Marija, 2011-08-25,
Reviewed: Heldin, CH, 2008-02-12 09:44:02
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GRB2:SOS1 complex binds to EGF:EGFR complex
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