Source:http://www.reactome.org/biopax/48887BiochemicalReaction160
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Authored: Gopinathrao, G, 2004-06-23 11:10:00,
TFIIS reactivates arrested RNA Pol II directly interacting with the enzyme resulting in endonucleolytic excision of nascent transcript ~7-14 nucleotides upstream of the 3' end. This reaction is catalyzed by the catalytic site and results in the generation of a new 3'-OH terminus that could be used for re-extension from the correctly base paired site (reviewed by Shilatifard et al., 2003).
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TFIIS-mediated recovery of elongation from arrest
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