Source:http://www.reactome.org/biopax/48887BiochemicalReaction1589
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Authored: Le Novere, N, Jassal, B, 2004-03-31 12:22:05,
Edited: Jassal, B, 2006-10-10 09:20:18,
Reviewed: Gillespie, ME, 2009-06-02 00:56:21,
The IP3 receptor (IP3R) is an IP3-gated calcium channel. It is a large, homotetrameric protein, similar to other calcium channel proteins such as ryanodine. The four subunits form a 'four-leafed clover' structure arranged around the central calcium channel. Binding of ligands such as IP3 results in conformational changes in the receptor's structure that leads to channel opening.
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IP3 binds to the IP3 receptor, opening the endoplasmic reticulum Ca2+ channel
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