Source:http://www.reactome.org/biopax/48887BiochemicalReaction1496
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Authored: Bortz, E, Garcia-Sastre, A, 2007-02-12 19:39:05,
Reviewed: Squires, B, 2007-02-12 19:39:22,
Viral vRNA, complexed with NP protein, is bound by the trimeric viral polymerase complex in a stable secondary structure-dependent manner, referred to as a panhandle, fork or cork-screw (Fodor, 1994; Brownlee, 2002; Park, 2003; Crow, 2004). This RNA structure is made of both the 5� and 3' ends of the vRNA. The polymerase is thought to first bind the 5' end of the vRNA and then the 3' end. Synthesis of cRNA initiates without a host cell methylated RNA cap as a primer (Beaton, 1986; Galarza, 1996; Deng, 2006; Engehardt, 2006).
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| biopax3:xref |
http://identifiers.org/pubmed/12072510,
http://identifiers.org/pubmed/12771209,
http://identifiers.org/pubmed/15163719,
http://identifiers.org/pubmed/16474140,
http://identifiers.org/pubmed/16933365,
http://identifiers.org/pubmed/3462695,
http://identifiers.org/pubmed/8189550,
http://identifiers.org/pubmed/8642663,
urn:biopax:UnificationXref:REACTOME DATABASE ID_192832,
urn:biopax:UnificationXref:REACTOME_REACT_9513_2
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Initiation of cRNA Synthesis
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2.7.7.48
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