Source:http://www.reactome.org/biopax/48887BiochemicalReaction1495
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Authored: Bortz, E, Garcia-Sastre, A, 2007-02-12 19:39:05,
Reviewed: Squires, B, 2007-02-12 19:39:22,
The viral polymerase complex produces positive-sense viral mRNA with host-cell derived 5' methyl caps. Capped viral mRNAs are selectively exported from the host cell nucleus through a currently unclear mechanism that may rely on components of the host cell mRNA export machinery (Chen, 2000; Engelhardt, 2006). Polyadenylation of viral mRNA appears be required for influenza mRNA export (Poon, 2000). A coupling of viral mRNA export with cellular pre-mRNA processing complexes, recruited by phosphorylation of host RNA polymerase II C-terminal domain which interacts with the viral polymerase (Engelhardt, 2005), has been proposed as controlling the export of a subset (M1, HA, and NS1, but not NP) of viral mRNA from the nucleus (Amorim, 2007).
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| biopax3:xref |
http://identifiers.org/pubmed/10590131,
http://identifiers.org/pubmed/10920397,
http://identifiers.org/pubmed/15827195,
http://identifiers.org/pubmed/16933365,
http://identifiers.org/pubmed/17132145,
urn:biopax:UnificationXref:REACTOME DATABASE ID_192627,
urn:biopax:UnificationXref:REACTOME_REACT_9529_1
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Viral mRNA Export
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