Source:http://www.reactome.org/biopax/48887BiochemicalReaction1489
| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
Authored: Bortz, E, Garcia-Sastre, A, 2007-02-12 19:39:05,
Reviewed: Squires, B, 2007-02-12 19:39:22,
The 5' end of the vRNA associates with a binding site on the PB1 subunit of the viral RNA polymerase, distinct from the 3' vRNA binding site, which is subsequenty bound forming a loop. These binding events set off allosteric conformational changes in the trimeric polymerase complex that induce PB2 binding of the methylated cap on a host pre-mRNA (Plotch, 1981; Cianci, 1995; Li, 1998; Brownlee, 2002; Kolpashchikov, 2004). PB2 amino acids 242-282 and 538-577 are involved in cap binding (Honda, 1999). Direct or indirect interaction with active, transcribing host RNA polymerase II is thought to supply host mRNA for the caps (Bouloy, 1978; Engelhardt, 2005).
|
| biopax3:xref |
http://identifiers.org/pubmed/10526235,
http://identifiers.org/pubmed/12072510,
http://identifiers.org/pubmed/15134462,
http://identifiers.org/pubmed/15827195,
http://identifiers.org/pubmed/283399,
http://identifiers.org/pubmed/6261960,
http://identifiers.org/pubmed/7769657,
http://identifiers.org/pubmed/9755184,
urn:biopax:RelationshipXref:GENE ONTOLOGY_GO:0019083,
urn:biopax:UnificationXref:REACTOME DATABASE ID_168326,
urn:biopax:UnificationXref:REACTOME_REACT_6142_3
|
| biopax3:dataSource | |
| biopax3:displayName |
Assembly of an Active Transcription Complex
|
| biopax3:left | |
| biopax3:right |