Source:http://www.reactome.org/biopax/48887BiochemicalReaction1446
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Authored: Matthews, L, 2006-06-07 20:09:24,
During reverse transcription, APOBEC3G-mediated minus-strand deamination occurs within a CC dinucleotide context over the entire length of the HIV-1 genome (Yu et al., 2004). <br>The polypurine tract is essential for plus strand synthesis and is located at the 3� end of the retroviral genome. HIV-1 encodes an additional central polypurine tract located in the middle of the genome which also serves as primer for plus strand synthesis.<br>Deamination of the minus strand continues throughout its synthesis with the frequency of deamination events increasing from the 5� to 3� regions. A 400bp region downstream of the central polypurine tract seems to be protected from deamination (Wurtzer et al., 2006),
Edited: Matthews, L, 2007-01-30 11:27:41,
Reviewed: Mulder, L, 2007-01-30 22:57:00,
Reviewed: Simon, V, 2007-01-30 23:07:12
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Deamination of C residues during synthesis of HIV-1 reverse transcript minus-strand
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3.5.4.13
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