Source:http://www.reactome.org/biopax/48887BiochemicalReaction1420
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Authored: Matthews, L, Rice, AP, 2005-07-27 00:00:00,
Edited: Matthews, L, 2005-07-26 23:29:22,
Pol II pausing is believed to result from reversible backtracking of the Pol II enzyme complex by ~2 to 4 nucleotides. This leads to misaligned 3'-OH terminus that is unable to be an acceptor for the incoming NTPs in synthesis of next phosphodiester bond (reviewed by Shilatifard et al., 2003).
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2-4 nt.backtracking of Pol II complex on the HIV-1 template leading to elongation pausing
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