Source:http://www.reactome.org/biopax/48887BiochemicalReaction1410
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Authored: Matthews, L, Rice, AP, 2005-07-27 00:00:00,
Edited: Matthews, L, 2005-07-26 23:29:22,
RNA Pol II arrest is believed to be a result of irreversible backsliding of the enzyme by ~7-14 nucleotides. It is suggested that, arrest leads to extrusion of displaced transcripts 3'-end through the small pore near the Mg2+ ion. Pol II arrest may lead to abortive termination of elongation due to irreversible trapping of the 3'-end of the displaced transcript in the pore (reviewed by Shilatifard et al., 2003).
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7-14 nt. Backtracking of Pol II complex on the HIV-1 template leading to elongation arrest
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