Source:http://www.reactome.org/biopax/48887BiochemicalReaction1384
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Authored: Matthews, L, Rice, AP, 2005-07-27 00:00:00,
Edited: Matthews, L, 2005-07-26 23:29:22,
Formation of the third phosphodiester bond creates a 4-nt product. This commits the initiation complex to promoter escape. The short 4-nt transcript is still loosely associated with the RNA polymerase II initiation complex and can dissociate to yield abortive products, which are not further extended. Inhibition of ATP-hydrolysis by TFIIH does not lead to collapse of the open region any longer. The transcription complex has lost the sensitivity to single-stranded oligo-nucleotide inhibition. However, ATP-hydrolysis and TFIIH are required for efficient promoter escape. The open region (ââ?¬Å?transcription bubbleââ?¬Â?) expands concomitant with the site of RNA-extension. In this case this region spans positions -9 to +4.
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Addition of the fourth nucleotide on the nascent HIV-1 transcript: Second Transition
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2.7.7.6
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