Source:http://www.reactome.org/biopax/48887BiochemicalReaction1333
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Authored: May, B, 2011-02-13,
Edited: May, B, 2011-02-13,
Reviewed: Peng, C, 2011-08-24,
SMAD2 and SMAD3 do not bind DNA efficiently. They must interact with DNA-binding proteins to activate transcription. FOXH1 interacts with phospho-SMAD2 and phospho-SMAD3 complexed with CO-SMAD (SMAD4) at promoters containing the Activin Response Element (Zhou et al. 1998, Yanagisawa et al. 2000).
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Phospho R-SMAD(SMAD2/3):CO-SMAD(SMAD4):FOXH1 Binds Activin Response Element
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