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Authored: May, B, 2011-01-23, Edited: May, B, 2011-01-23, NODAL binds a receptor comprising a type I activin receptor (ACVR1B or ACVR1C), a type II activin receptor (ACVR2 or ACVR2B), and a EGF-CFC coreceptor (CRIPTO or CRYPTIC). Though NODAL is able to signal via the ACVR1C (ALK7) receptor (Reissman et al. 2001), experiments in mouse indicate NODAL signaling via ALK7 is dispensable during embryogenesis (Jornvall et al. 2004)., Reviewed: Peng, C, 2011-08-24
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The NODAL Receptor Binds NODAL Ligands
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