Source:http://www.reactome.org/biopax/48887BiochemicalReaction13
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Authored: May, B, 2009-07-22,
Edited: May, B, 2009-07-22,
Reviewed: Wilusz, J, 2009-09-17,
The PAN2-PAN3 exoribonuclease complex hydrolyzes the poly(A) tail of a mRNA, shortening the tail from about 200 adenosine residues to about 80 adenosine residues and yielding adenosine 5'-monophosphate. PAN2 is the exoribonuclease component of the complex; PAN3 is required for cellular localization. The poly(A)-binding protein (PABP) interacts with PAN3 and recruits the PAN2-PAN3 complex to mRNA.
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| biopax3:xref |
http://identifiers.org/pubmed/11283721,
http://identifiers.org/pubmed/14583602,
http://identifiers.org/pubmed/14749774,
http://identifiers.org/pubmed/15475613,
http://identifiers.org/pubmed/16141059,
http://identifiers.org/pubmed/16284618,
http://identifiers.org/pubmed/17245413,
http://identifiers.org/pubmed/17595167,
http://identifiers.org/pubmed/18625844,
http://identifiers.org/pubmed/19239894,
urn:biopax:UnificationXref:REACTOME DATABASE ID_430021,
urn:biopax:UnificationXref:REACTOME_REACT_20606_1
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Partial Deadenylation of mRNA by the PAN2-PAN3 Complex
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3.1.13.4
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