Source:http://www.reactome.org/biopax/48887BiochemicalReaction1276
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Ankyrins are bifunctional linker proteins that tether L1 to the membrane associated, spectrin based actin cytoskeleton. Spectrin is a tetramer of two alpha- and two beta-chains. The spectrin alpha chain has 21 and the beta chain has 16 (conventional beta) or 30 (heavy beta) successive triple helix repeats. At the N-terminus of beta spectrin, there is a pair of CH (calponin homology) domains which together form an actin binding domain, while the triple helical repeats 14-15 bind ankyrin. <br>Interaction with spectrin bound F-actin blocks the mobility of L1 and this immobilization mediates adjacent neuron adhesions.,
Authored: Garapati, P V, 2008-07-30 10:22:58,
Edited: Garapati, P V, 2008-07-30 10:22:58,
Reviewed: Maness, PF, 2010-02-16
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L1 linked to actin cytoskeleton by ankyrin
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