Source:http://www.reactome.org/biopax/48887BiochemicalReaction1245
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Authored: Garapati, P V, 2008-09-05 06:02:05,
Edited: Garapati, P V, 2008-09-05 06:02:05,
Reviewed: Kidd, T, 2009-08-18,
Slit 2 and both its natural cleavage products bind glypican 1, a glycosyl phosphatidyl inositol (GPI) anchored heparan sulfate proteoglycan (HSPG) through its C terminus. Glypican 1 HSPG is important for high affinity binding of Slit to its receptor and for the repulsive activity of Slit. Slit-Robo signaling strictly requires binding to heparan sulfate. HSPGs may also modulate the extracellular distribution or stability of Slit proteins.
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Glypican-1 binds Slit2
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