Source:http://www.reactome.org/biopax/48887BiochemicalReaction1223
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Authored: Garapati, P V, 2008-07-16 14:42:16,
Edited: Garapati, P V, 2008-07-30 10:24:23,
Reviewed: Cooper, HM, 2010-02-16,
Unc-115/AbLIM is a key regulator of lamellipodia and filopodia in the growth cone during axon pathfinding and acts downstream of Rac GTPase signaling. It acts as a scaffold to recruit other actin-modulating complexes involved in lamellipodia and filopodia. Unc-115/AbLIM is locally recruited to the plasma membrane by activated Rac1 and subsequently dephosphorylated on serine 617. Dephosphorylated Unc-115/AbLIM then might interact with other molecules at the plasma membrane to induce formation of lamellipodia and filopodia by reorganization of the actin cytoskeleton.
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Recruitment of ABLIM to the plasma membrane
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