Source:http://www.reactome.org/biopax/48887BiochemicalReaction1220
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Authored: Garapati, P V, 2008-07-16 14:42:16,
Edited: Garapati, P V, 2008-07-30 10:24:23,
Reviewed: Cooper, HM, 2010-02-16,
RhoGEF complexed with Netrin-1-DCC induces guanine nucleotide exchange by Cdc42, activating it. Activated Cdc42 activates N-WASP, which promotes the nucleation of F-actin via the Arp2/3 complex. Netrin-1, via DCC, influences cellular motility by regulating actin-based membrane extension through the activation of Cdc42.
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Activation of Cdc42
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