Source:http://www.reactome.org/biopax/48887BiochemicalReaction1219
| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
Authored: Garapati, P V, 2008-07-16 14:42:16,
Edited: Garapati, P V, 2008-07-30 10:24:23,
Reviewed: Cooper, HM, 2010-02-16,
When Netrin-1 binds to the DCC-NCK1 complex, a conformational change in NCK1 promotes interaction between the SH2 domain proteins, leading to recruitment and activation of RhoGEFs DOCK180 and Trio. These GEFs mediate Netrin-1 signaling in axon outgrowth and guidance through their ability to activate Rac1 and Cdc42.
|
| biopax3:xref |
http://identifiers.org/pubmed/11817894,
http://identifiers.org/pubmed/12149262,
http://identifiers.org/pubmed/15788770,
http://identifiers.org/pubmed/18066058,
http://identifiers.org/pubmed/18212043,
urn:biopax:UnificationXref:REACTOME DATABASE ID_418858,
urn:biopax:UnificationXref:REACTOME_REACT_22278_2
|
| biopax3:dataSource | |
| biopax3:displayName |
RhoGTPase GEF's recruited to DCC
|
| biopax3:left | |
| biopax3:right |