Source:http://www.reactome.org/biopax/48887BiochemicalReaction1218
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Authored: Garapati, P V, 2008-07-16 14:42:16,
DCC interacts with the SH3/SH2 adaptor NCK1 in commissural neurons. This interaction is direct and requires the SH3 but not SH2 domains of NCK1. NCK1 can recruit Rac, Cdc42 and their effectors Pak and N-WASP to the activated receptor, thereby providing a direct link between DCC, Rho GTPases and numerous downstream signaling components that regulate the actin cytoskeleton.,
Edited: Garapati, P V, 2008-07-30 10:24:23,
Reviewed: Cooper, HM, 2010-02-16
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DCC interacting NCK-1
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