Source:http://www.reactome.org/biopax/48887BiochemicalReaction1209
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Authored: Garapati, P V, 2009-02-24 10:31:15,
Edited: Garapati, P V, 2009-02-24 10:58:20,
NCAM1 has been demonstrated to possess (Ca++ or Mg++) dependant ATP hydrolyzing activity. ATP can bind to NCAM directly and that NCAM can act as an ecto-ATPase hydrolyzing around 1000 molecules of ATP/minute. Binding of ATP to NCAM1 inhibits cellular aggregation and neurite outgrowth induced by NCAM1-FGFR binding. The NCAM binding site to ATP overlaps with the site of NCAM-FGFR interaction, and ATP is capable of disrupting NCAM-FGFR binding.,
Reviewed: Maness, PF, Walmod, PS, 2009--0-5-
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NCAM1 binds to ATP
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