Source:http://www.reactome.org/biopax/48887BiochemicalReaction1185
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An unidentified protein tyrosine kinase located in the plasma membrane phosphorylates tyrosine residues at 340 and 341 (Y1, Y2 in diagram) of Raf-1. This serves to further stabilise the active 'open' Raf-1 conformation. While the kinase has not been definitively identified, Src is a plausible candidate: coexpression of Raf-1 and Src in Sf9 cells resulted in phosphorylation of Y340/Y341 and enzymatic activationof Raf-1; Raf-1 interacts with Src and co-immunoprecipitates with Src/Fyn in NIH-3T3 cells.,
Authored: Charalambous, M, 2005-01-07 11:17:43,
Edited: Schmidt, EE, 0000-00-00 00:00:00
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Stabilisation of RAF by further phosphorylation
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2.7.10
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