Source:http://www.reactome.org/biopax/48887BiochemicalReaction1181
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Authored: Garapati, P V, 2009-02-24 10:31:15,
Edited: Garapati, P V, 2009-02-24 10:58:20,
Reviewed: Maness, PF, Walmod, PS, 2009--0-5-,
The guanine nucleotide exchange factor SOS interacts with GRB2 bound to phosphorylated FAK bound to NCAM. Upon formation of this complex, SOS activates Ras by promoting GDP release and GTP binding.
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NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras
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