Source:http://www.reactome.org/biopax/48887BiochemicalReaction1180
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Authored: Garapati, P V, 2009-02-24 10:31:15,
Edited: Garapati, P V, 2009-02-24 10:58:20,
Guanine nucleotide releasing factor Sos associates with FAK bound Grb2 to activate Ras and initiate Ras-MAPK signaling. This interaction occurs between the carboxy terminal domain of SOS and the Src homology 3 (SH3) domains of GRB2.,
Reviewed: Maness, PF, Walmod, PS, 2009--0-5-
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SOS binds Grb2 bound to pFAK:NCAM1
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