Source:http://www.reactome.org/biopax/48887BiochemicalReaction1173
| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
Authored: Garapati, P V, 2009-02-24 10:31:15,
Edited: Garapati, P V, 2009-02-24 10:58:20,
FGFR is one of the heterophilic interactors of NCAM. The FG loop region of the second Fn3 module of NCAM binds to Ig domains 2 and 3 of FGFR. The FGFR binding site to NCAM overlaps with the site of NCAM-ATP interaction, and ATP is capable of disrupting NCAM-FGFR binding and signaling. <br>The interaction of NCAM activates FGFR and NCAM might merely mimic FGF's in FGFR stimulation, but there is a difference in the activation pattern induced by NCAM and FGF-2. NCAM activated FGFR stimulates neurite outgrowth by stimulating PLCgamma and DAG lipase leading to generation of arachidonic acid.,
Reviewed: Maness, PF, Walmod, PS, 2009--0-5-
|
| biopax3:xref | |
| biopax3:dataSource | |
| biopax3:displayName |
NCAM1 binds FGFR-1
|
| biopax3:left | |
| biopax3:right |