Source:http://www.reactome.org/biopax/48887BiochemicalReaction1172
| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
Antiparallel NCAM interactions involve trans-interactions of NCAM molecules on opposed cell membranes. Based on structural and functional studies a 'double zipper' model has been proposed to describe these interactions. The first model - the 'flat zipper'- formed between NCAM1 cis-dimers from one cell surface interacting in trans through IgII-IgIII contacts with NCAM1 cis-dimers from another cell surface. The second model - the 'compact zipper'- is formed between NCAM1 cis-dimers from one cell surface interacting in trans through IgI-IgIII and IgII-IgII contacts with cis-dimers from another cell surface.<p>Abrogation of cis-dimerization inhibits NCAM mediated neurite outgrowth, and cis-dimerization of NCAM1 may be a necessary prerequisite for subsequent trans-interactions.,
Authored: Garapati, P V, 2009-02-24 10:31:15,
Edited: Garapati, P V, 2009-02-24 10:58:20,
Reviewed: Maness, PF, Walmod, PS, 2009--0-5-
|
| biopax3:xref | |
| biopax3:dataSource | |
| biopax3:displayName |
NCAM1 trans-homophilic interaction
|
| biopax3:left | |
| biopax3:participantStoichio... | |
| biopax3:right |