Source:http://www.reactome.org/biopax/48887BiochemicalReaction1158
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Authored: Garapati, P V, 2009-03-23 09:59:28,
Cofilin is a member of the ADF (actin-depolymerizing factor) protein family, that is involved in regulating actin dynamics in the growth cone. It binds to actin in a one-to-one molar ratio, and stimulates both the severing of actin filaments and depolymerization of actin subunits from the actin filament end. <br>Activated LIMK phosphorylates cofilin on conserved serine 3 (Ser3/S3), located near the actin binding site. After phosphorylation cofilin is inactive and looses its affinity for actin and releases from G-actin monomers. Now the ADP-actin monomers are free and can exchange ADP with cytoplasmic ATP and they are ready for reincorporation at the barbed end of the a growing filament.,
Edited: Garapati, P V, 2009-03-23 10:00:07,
Reviewed: Kumanogoh, A, Kikutani, H, 2009-09-01
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Phosphorylation of cofilin by LIMK-1
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2.7.11
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