Source:http://www.reactome.org/biopax/48887BiochemicalReaction1145
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Authored: Garapati, P V, 2009-03-23 09:59:28,
Edited: Garapati, P V, 2009-03-23 10:00:07,
Reviewed: Kumanogoh, A, Kikutani, H, 2009-09-01,
The best characterized receptors for mediating semaphorin signaling are members of the neuropilin and plexin families of transmembrane proteins. Neuropilins form complexes with Plexin-A which in turn can act as a signaling moiety. Also, when complexed with neuropilin-1, plexin-A1 can associate directly with the FERM domain containing guanine nucleotide exchange factor (GEF) FARP2. FARP2 exerts GEF activity for Rac but not Cdc42 and Rho.
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Plexin-A binds to neuropilin-1
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