Source:http://www.reactome.org/biopax/48887BiochemicalReaction1140
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Authored: Akkerman, JW, 2009-06-03,
Edited: Jupe, S, 2009-05-20 09:50:28,
Reviewed: Kumanogoh, A, Kikutani, H, 2009-09-01,
Rho-associated, coiled-coil containing protein kinases (ROCKs) are primarily known as downstream effectors of Rho, but they can also be activated by arachidonic acid, which binds to the pleckstrin homology domain, releasing an autoinhibitory loop within ROCK allowing catalytic activity. Multiple targets of ROCK contribute to the stabilization of actin filaments and the generation of actin-myosin contractile force.
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ROCK activation by Rho
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