Source:http://www.reactome.org/biopax/48887BiochemicalReaction1138
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Authored: Garapati, P V, 2009-03-23 09:59:28,
Edited: Garapati, P V, 2009-03-23 10:00:07,
Plexin-B1 activates RhoA and induces growth cone collapse and and cytoskeletal reorganization through Rho-specific guanine nucleotide exchange factors PDZ-RhoGEF and leukemia-associated RhoGEF (LARG). Plexin-B1 directly interacts with PDZ-RhoGEF through its c-terminal PDZ domain binding motif. It has been suggested that Rnd1, which binds to the cytoplasmic part of plexin-B1, can promote the interaction between plexin-B1 and PDZ-RhoGEF. The PDZ domain of LARG is directly involved in the interaction with the c-terminal sequence of Plexin-B1.,
Reviewed: Kumanogoh, A, Kikutani, H, 2009-09-01
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LARG and PDZ-RhoGEF binds to Plexin-B1
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