Source:http://www.reactome.org/biopax/48887BiochemicalReaction1134
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Authored: Garapati, P V, 2009-03-23 09:59:28,
Edited: Garapati, P V, 2009-03-23 10:00:07,
Plexin-B1 functions as an R-Ras GTPase-activating protein (GAP) and directly and specifically down regulates R-Ras activity in response to Sema4D, inducing growth cone collapse. R-Ras inactivation promotes PI3K and Akt inactivation followed by GSK-3beta activation and CRMP inactivation. R-Ras inactivation also inhibits cell migration by regulating beta1 integrin activity. <br>,
Reviewed: Kumanogoh, A, Kikutani, H, 2009-09-01
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Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity
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