Source:http://www.reactome.org/biopax/48887BiochemicalReaction1133
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Authored: Garapati, P V, 2009-03-23 09:59:28,
Edited: Garapati, P V, 2009-03-23 10:00:07,
Reviewed: Kumanogoh, A, Kikutani, H, 2009-09-01,
Rnd1 is constitutively active and stably associates with Plexin-B1 and regulates the R-Ras GAP activity of the C1 and C2 domains of the Plexin-B1 cytoplasmic tail. These domains interact with each other and in this closed conformation cannot associate with active R-Ras-GTP. Rnd1 binds to the region between C1 and C2 domains and disrupts this interaction, allowing the receptor to associate with GTP-bound R-Ras.
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Rnd1 interacts with Plexin-B1:Sema4D
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