Source:http://www.reactome.org/biopax/48887BiochemicalReaction1130
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Authored: Orlic-Milacic, M, 2011-11-04,
Edited: Matthews, L, 2011-11-07,
Reviewed: Neckers, LM, 2011-11-11,
Reviewed: Xu, W, 2011-11-11,
Sos1 bound to exogenously expressed human GRB2 in complex with phosphorylated mouse Shc1 and phosphorylated rat oncoprotein Erbb2mut catalyzes guanyl-nucleotide exchange on endogenous Ras in mouse fibroblasts.
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Ras guanyl-nucleotide exchange mediated by Sos1 bound to GRB2 in complex with P-Shc1:P-Erbb2mut
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