Source:http://www.reactome.org/biopax/48887BiochemicalReaction1058
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Authored: Ouwehand, W.H., 2007-11-12 16:45:54,
Reviewed: Zwaginga, JJ, 2007-11-12 16:47:00,
The triggering receptor expressed on myeloid cells 1 (TREM-1) plays an important role in the innate immune response related to severe infections and sepsis. Although the identity and occurrence of the natural TREM-1 ligands are so far unknown, the presence of a ligand for TREM-1 on human platelets has been established. It has been suggested that TREM1 recognizes soluble proteins or cell-surface proteins which are upregulated as a result of inflammation and/or tissue damage and also bacterial LPS (Tessarz & Cerwenka 2008).
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Platelet-derived TREM-1 ligand binds to TREM-1
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