Source:http://www.reactome.org/biopax/48887BiochemicalReaction1048
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Authored: Ouwehand, W.H., 2007-11-12 16:45:54,
PSGL-1 is expressed as a homodimer of two 120-kDa subunits that binds all three selectins, with the highest affinity for P-selectin, and is known to be constitutively expressed on the surface of platelets and most types of leukocytes. Besides playing a critical role in the inflammatory response by mediating leukocyte-leukocyte and leukocyte-endothelium interactions, PSGL-1 also participates in the hemostatic process by mediating leukocyte-platelet interactions.,
Reviewed: Zwaginga, JJ, 2007-11-12 16:47:00
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P-selectin binds P-selectin ligand
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